Browsing Centre for Genomics and Child Health by Title
Now showing items 332-351 of 835
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Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child.
(2017)OBJECTIVE: The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with ... -
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
(2021-03-11)Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer's disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome ... -
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
(Nature Research, 2024-02-19)Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution ... -
Genetic mechanisms of critical illness in Covid-19.
(2020-12-11)Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 ... -
Genome wide whole blood transcriptome profiling across inherited bone marrow failure subtypes.
(2021-10-08)Gene expression profiling has long been used in understanding the contribution of genes and related pathways in disease pathogenesis and susceptibility. We have performed whole blood transcriptomic profiling in a subset ...