Browsing Centre for Genomics and Child Health by Title
Now showing items 308-327 of 835
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FASN activity is important for the initial stages of the induction of senescence
(Springer Nature, 2019-04-08)Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is characterized ... -
Feasibility and acceptability of a primary care liver fibrosis testing pathway centred on the diabetes annual review: PRELUDE1 prospective cohort study protocol.
(2023-05-19)INTRODUCTION: Non-alcoholic fatty liver disease is the most common chronic liver disease worldwide affecting 20%-25% in the USA and Europe with a 60%-80% lifetime prevalence for people with type 2 diabetes (T2D). Fibrosis ... -
Fetal haemopoiesis marking low-grade urinary bladder cancer
(2012-07-24) -
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
(2015-05-27)© 2015 Nature America, Inc. All rights reserved. Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine ... -
First analysis of the Severe Paediatric Asthma Collaborative in Europe registry.
(2020-10)New biologics are being continually developed for paediatric asthma, but it is unclear whether there are sufficient numbers of children in Europe with severe asthma and poor control to recruit to trials needed for registration. ... -
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
(2018-02-19)Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...