Browsing Centre for Genomics and Child Health by Title
Now showing items 720-739 of 835
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Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products
(Wiley Online, 2013-02-12)Infection of the human host by schistosome parasites follows exposure of skin to free‐swimming cercariae and is aided by the release of excretory/secretory (E/S) material, which is rich in proteases and glycoconjugates. ... -
Schistosomiasis in the first 1000 days
(2018-06) -
School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review.
(Wiley, 2019-01-28)BACKGROUND: Asthma is a common respiratory condition in children that is characterised by symptoms including wheeze, shortness of breath, chest tightness, and cough. Children with asthma may be able to manage their condition ... -
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans.
(2017-12-19)Background: DUOX2 and DUOXA2 form the predominant H2O2-producing system in human colorectal mucosa. Inflammation, hypoxia, and 5-aminosalicylic acid increase H2O2 production, supporting innate defense and mucosal healing. ... -
SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells.
(2018-01-19)BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ... -
Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.
(2023-11-03)Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) ... -
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency
(Elsevier, 2013) -
Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry.
(2018-06)The development of new asthma biologics and receptor blockers for the treatment of paediatric severe asthma raises challenges. It is unclear whether there are sufficient children in Europe to recruit into randomised ... -
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease.
(Wiley, 2024-04-29)Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages ...