Browsing Centre for Genomics and Child Health by Title
Now showing items 348-367 of 831
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Genome wide whole blood transcriptome profiling across inherited bone marrow failure subtypes.
(2021-10-08)Gene expression profiling has long been used in understanding the contribution of genes and related pathways in disease pathogenesis and susceptibility. We have performed whole blood transcriptomic profiling in a subset ... -
Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.
(2023-10-23)Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide ... -
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
(2020-10-15)BACKGROUND: There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide ... -
The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation
The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ~46kb (<0.002% genome), is the second most abundant cellular transcript. tRNAs also control ... -
Glucose testing in the neonate
(Elsevier, 1997-05-29)