Browsing Centre for Cell Biology and Cutaneous Research by Author "Rahman, MM"
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Differential expression of phosphorylated MEK and ERK correlates with aggressive BCC subtypes.
Rahman, MM; Herath, D; Bladen, JC; Atkar, R; Pirzado, MS; Harwood, C; Philpott, MP; Neill, GW (2021-07-16)Basal cell carcinoma (BCC) is associated with aberrant Hedgehog (HH) signalling through mutational inactivation of PTCH1; however, there is conflicting data regarding MEK/ERK signalling in BCC and the signalling pathway ... -
Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma.
Setúbal Destro Rodrigues, MF; Gammon, L; Rahman, MM; Biddle, A; Nunes, FD; Mackenzie, IC (2018-03-02)The therapeutic responses of many solid tumours to chemo- and radio-therapies are far from fully effective but therapies targeting malignancy-related cellular changes show promise for further control. In head and neck ... -
A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.
Rahman, MM; Hazan, A; Selway, JL; Herath, DS; Harwood, CA; Pirzado, MS; Atkar, R; Kelsell, DP; Linton, KJ; Philpott, MP (2018-05-15)Small-molecule inhibitors of the Hedgehog (HH) pathway receptor Smoothened (SMO) have been effective in treating some patients with basal cell carcinoma (BCC), where the HH pathway is often activated, but many patients ...