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dc.contributor.authorKarampatsas, K
dc.contributor.authorOsborne, L
dc.contributor.authorSeah, M-L
dc.contributor.authorTong, CYW
dc.contributor.authorPrendergast, AJ
dc.date.accessioned2019-02-27T12:49:22Z
dc.date.available2018-02-22
dc.date.available2019-02-27T12:49:22Z
dc.date.issued2018-03-22
dc.identifier.citationKarampatsas K, Osborne L, Seah M-L, Tong CYW, Prendergast AJ (2018) Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study. PLoS ONE 13(3): e0194009. https://doi.org/10.1371/journal.pone.0194009en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/55584
dc.description.abstractBACKGROUND: Rotavirus is the leading cause of acute gastroenteritis in children and is associated with neurological complications such as seizures and encephalopathy. The aim of this study was to investigate the presentation and complications of rotavirus compared to non-rotavirus gastroenteritis in UK children. METHODS: This was a retrospective, case-control, hospital-based study conducted at three sites in east London, UK. Cases were children aged 1 month to 16 years diagnosed with acute gastroenteritis between 1 June 2011 and 31 December 2013, in whom stool virology investigations confirmed presence of rotavirus by PCR. They were matched by age, gender and month of presentation to controls with rotavirus-negative gastroenteritis. RESULTS: Data were collected from 116 children (50 cases and 66 controls). Children with rotavirus gastroenteritis tended to present more frequently with metabolic acidosis (pH 7.30 vs 7.37, P = 0.011) and fever (74% versus 46%; P = 0.005) and were more likely to require hospitalisation compared to children with non-rotavirus gastroenteritis (93% versus 73%; P = 0.019). Neurological complications were the most common extra-intestinal manifestations, but did not differ significantly between children with rotavirus-positive gastroenteritis (RPG) and rotavirus-negative gastroenteritis (RNG) (24% versus 15%, respectively; P = 0.24). Encephalopathy occurred only in children with rotavirus infection (n = 3, 6%). CONCLUSION: Rotavirus causes longer and more severe disease compared to other viral pathogens. Seizures and milder neurological signs were surprisingly common and associated with multiple pathogens, but encephalopathy occurred only in children with rotavirus gastroenteritis. Rotavirus vaccination may reduce seizures and presentation to hospital, but vaccines against other pathogens causing gastroenteritis are required.en_US
dc.description.sponsorshipAJP receives funding from the Wellcome Trust (grant 108065/Z/15/Z).en_US
dc.format.extente0194009 - ?
dc.languageeng
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS One
dc.rightsCreative Commons Attribution License
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAdolescenten_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectFecesen_US
dc.subjectFemaleen_US
dc.subjectGastroenteritisen_US
dc.subjectHospitalizationen_US
dc.subjectHumansen_US
dc.subjectInfanten_US
dc.subjectInfant, Newbornen_US
dc.subjectLondonen_US
dc.subjectMaleen_US
dc.subjectRetrospective Studiesen_US
dc.subjectRotavirusen_US
dc.subjectRotavirus Infectionsen_US
dc.subjectRotavirus Vaccinesen_US
dc.subjectVaccinationen_US
dc.titleClinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective case-control study.en_US
dc.typeArticleen_US
dc.rights.holder2018 Karampatsas et al.
dc.identifier.doi10.1371/journal.pone.0194009
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29565992en_US
pubs.issue3en_US
pubs.notesNo embargoen_US
pubs.publication-statusPublished onlineen_US
pubs.volume13en_US
dcterms.dateAccepted2018-02-22
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderThe impact of cotrimoxazole on healthly birth and growth in rural Zimbabwe::Wellcome Trusten_US


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