dc.contributor.author | Turner, JD | |
dc.contributor.author | Meurs, L | |
dc.contributor.author | Dool, P | |
dc.contributor.author | Bourke, CD | |
dc.contributor.author | Mbow, M | |
dc.contributor.author | Dièye, TN | |
dc.contributor.author | Mboup, S | |
dc.contributor.author | Polman, K | |
dc.contributor.author | Mountford, AP | |
dc.date.accessioned | 2019-02-13T15:43:09Z | |
dc.date.available | 2019-02-13T15:43:09Z | |
dc.date.issued | 2013-02-12 | |
dc.identifier.citation | Turner, J. D., Meurs, L. , Dool, P. , Bourke, C. D., Mbow, M. , Dièye, T. N., Mboup, S. , Polman, K. and Mountford, A. P. (2013), Schistosome infection is associated with enhanced whole‐blood IL‐10 secretion in response to cercarial excretory/secretory products. Parasite Immunol, 35: 147-156. doi:10.1111/pim.12028 | en_US |
dc.identifier.issn | 0141-9838 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/55315 | |
dc.description | This is the peer reviewed version of the following article: Turner, J. D., Meurs, L. , Dool, P. , Bourke, C. D., Mbow, M. , Dièye, T. N., Mboup, S. , Polman, K. and Mountford, A. P. (2013), Schistosome infection is associated with enhanced whole‐blood IL‐10 secretion in response to cercarial excretory/secretory products. Parasite Immunol, 35: 147-156. doi:10.1111/pim.12028, which has been published in final form at https://doi.org/10.1111/pim.12028. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions | en_US |
dc.description.abstract | Infection of the human host by schistosome parasites follows exposure of skin to free‐swimming cercariae and is aided by the release of excretory/secretory (E/S) material, which is rich in proteases and glycoconjugates. This material provides the initial stimulus to cells of the innate immune system. The study presented here is the first to examine human innate/early immune responsiveness to cercarial E/S in subjects from an area co‐endemic for Schistosoma mansoni and S. haematobium. We report that in infected participants, stimulation of whole‐blood cultures with cercarial E/S material (termed 0–3 hRP) caused the early (within 24 h) release of greater quantities of regulatory IL‐10, compared with uninfected controls. Elevated levels of IL‐10 but not pro‐inflammatory TNFα or IL‐8 were most evident in participants co‐infected with S. mansoni and S. haematobium and were accompanied by a higher 0–3 h RP‐specific IL‐10: TNFα ratio. We also report that glycosylated components within 0–3 h RP appear to be important factors in the stimulation of IL‐8, TNFα and IL‐10 production by whole‐blood cells. | en_US |
dc.description.sponsorship | The European Union. Grant Number: EU INCO‐CT‐2006‐032405 | en_US |
dc.format.extent | 147 - 156 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley Online | en_US |
dc.relation.ispartof | Parasite Immunology | |
dc.rights | All rights reserved | |
dc.subject | cercariae | en_US |
dc.subject | excretory/seretory antigens | en_US |
dc.subject | human disease | en_US |
dc.subject | IL‐10 cytokine | en_US |
dc.subject | schistosomiasis | en_US |
dc.title | Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products | en_US |
dc.type | Article | en_US |
dc.rights.holder | 2013 John Wiley&Sons Ltd | |
dc.identifier.doi | 10.1111/pim.12028 | |
pubs.issue | 5-6 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 35 | en_US |
dcterms.dateAccepted | 2013-01-15 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |