dc.contributor.author | Shakoor, S | en_US |
dc.contributor.author | Zavos, HMS | en_US |
dc.contributor.author | Haworth, CMA | en_US |
dc.contributor.author | McGuire, P | en_US |
dc.contributor.author | Cardno, AG | en_US |
dc.contributor.author | Freeman, D | en_US |
dc.contributor.author | Ronald, A | en_US |
dc.date.accessioned | 2019-02-04T13:30:43Z | |
dc.date.issued | 2016-06 | en_US |
dc.identifier.issn | 0007-1250 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/55129 | |
dc.description.abstract | Background:
Stressful life events (SLEs) are associated with psychotic
experiences. SLEs might act as an environmental risk factor,
but may also share a genetic propensity with psychotic
experiences.
Aims:
To estimate the extent to which genetic and environmental
factors influence the relationship between SLEs and
psychotic experiences.
Method:
Self- and parent reports from a community-based twin
sample (4830 16-year-old pairs) were analysed using
structural equation model fitting.
Results:
SLEs correlated with positive psychotic experiences
(r = 0.12–0.14, all P50.001). Modest heritability was shown
for psychotic experiences (25–57%) and dependent SLEs
(32%). Genetic influences explained the majority of the
modest covariation between dependent SLEs and paranoia
and cognitive disorganisation (bivariate heritabilities 74–86%).
The relationship between SLEs and hallucinations and
grandiosity was explained by both genetic and common
environmental effects.
Conclusions:
Further to dependent SLEs being an environmental risk
factor, individuals may have an underlying genetic propensity
increasing their risk of dependent SLEs and positive
psychotic experiences.
Declaration of interest:
None. | |
dc.description.sponsorship | Medical Research Council | en_US |
dc.format.extent | 532 - 538 | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | British Journal of Psychiatry | en_US |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Association between stressful life events and psychotic experiences in adolescence: Evidence for gene–environment correlations | en_US |
dc.type | Article | |
dc.rights.holder | (c)The Royal College of Psychiatrists 2016. | |
dc.identifier.doi | 10.1192/bjp.bp.114.159079 | en_US |
pubs.issue | 06 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 208 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |