Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan.
dc.contributor.author | Grydeland, H | en_US |
dc.contributor.author | Vértes, PE | en_US |
dc.contributor.author | Váša, F | en_US |
dc.contributor.author | Romero-Garcia, R | en_US |
dc.contributor.author | Whitaker, K | en_US |
dc.contributor.author | Alexander-Bloch, AF | en_US |
dc.contributor.author | Bjørnerud, A | en_US |
dc.contributor.author | Patel, AX | en_US |
dc.contributor.author | Sederevicius, D | en_US |
dc.contributor.author | Tamnes, CK | en_US |
dc.contributor.author | Westlye, LT | en_US |
dc.contributor.author | White, SR | en_US |
dc.contributor.author | Walhovd, KB | en_US |
dc.contributor.author | Fjell, AM | en_US |
dc.contributor.author | Bullmore, ET | en_US |
dc.date.accessioned | 2019-01-17T11:19:41Z | |
dc.date.available | 2018-11-30 | en_US |
dc.date.issued | 2018-12-27 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/54734 | |
dc.description.abstract | Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of seven cytoarchitectonic classes. From the first derivatives of these generally inverted-U trajectories, we defined three milestones: the age at peak growth; the age at onset of a stable plateau; and the age at the onset of decline. Age at peak growth had a bimodal distribution comprising an early (pre-pubertal) wave of primary sensory and motor cortices and a later (post-pubertal) wave of association, insular and limbic cortices. Most regions reached stability in the 30-s but there was a second wave reaching stability in the 50-s. Age at onset of decline was also bimodal: in some right hemisphere regions, the curve declined from the 60-s, but in other left hemisphere regions, there was no significant decline from the stable plateau. These results are consistent with regionally heterogeneous waves of intracortical myelinogenesis and age-related demyelination. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Cereb Cortex | en_US |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan. | en_US |
dc.type | Article | |
dc.rights.holder | © The Author(s) 2018. | |
dc.identifier.doi | 10.1093/cercor/bhy330 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30590439 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2018-11-30 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.