Show simple item record

dc.contributor.authorThorneloe, RJen_US
dc.contributor.authorHorne, Ren_US
dc.contributor.authorSide, Len_US
dc.contributor.authorWolf, MSen_US
dc.contributor.authorSmith, SGen_US
dc.contributor.authorENGAGE Investigatorsen_US
dc.description.abstractINTRODUCTION: Uptake of preventive therapies for breast cancer is low. We examined whether women at increased risk of breast cancer can be categorized into groups with similar medication beliefs, and whether belief group membership was prospectively associated with uptake of preventive therapy. PATIENTS AND METHODS: Women (n = 732) attending an appointment to discuss breast cancer risk were approached; 408 (55.7%) completed the Beliefs About Medicines and the Perceived Sensitivity to Medicines questionnaires. Uptake of tamoxifen at 3 months was reported in 258 (63.2%). The optimal number of belief groups were identified using latent profile analysis. RESULTS: Uptake of tamoxifen was 14.7% (38/258). One in 5 women (19.4%; 78/402) reported a strong need for tamoxifen. The model fit statistics supported a 2-group model. Both groups held weak beliefs about their need for tamoxifen for current and future health. Group 2 (38%; 154/406 of the sample) reported stronger concerns about tamoxifen and medicines in general, and stronger perceived sensitivity to the negative effects of medicines compared with group 1 (62%; 252/406). Women with low necessity and lower concerns (group 1) were more likely to initiate tamoxifen (18.3%; 33/180) than those with low necessity and higher concerns (group 2) (6.4%; 5/78). After adjusting for demographic and clinical factors, the odds ratio was 3.37 (95% confidence interval, 1.08-10.51; P = .036). CONCLUSION: Uptake of breast cancer preventive therapy was low. A subgroup of women reported low need for preventive therapy and strong medication concerns. These women were less likely to initiate tamoxifen. Medication beliefs are targets for supporting informed decision-making.en_US
dc.format.extente116 - e126en_US
dc.relation.ispartofClin Breast Canceren_US
dc.rightsThis is an open access article under the CC BY license (
dc.subjectBreast cancer preventionen_US
dc.subjectMedication beliefsen_US
dc.titleBeliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study.en_US
dc.rights.holder© 2018 The Authors. Published by Elsevier Inc.
pubs.notesNot knownen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderCancer Prevention::Cancer Research UKen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record