dc.contributor.author | Church, JA | en_US |
dc.contributor.author | Rukobo, S | en_US |
dc.contributor.author | Govha, M | en_US |
dc.contributor.author | Carmolli, MP | en_US |
dc.contributor.author | Diehl, SA | en_US |
dc.contributor.author | Chasekwa, B | en_US |
dc.contributor.author | Ntozini, R | en_US |
dc.contributor.author | Mutasa, K | en_US |
dc.contributor.author | Humphrey, JH | en_US |
dc.contributor.author | Kirkpatrick, BD | en_US |
dc.contributor.author | Prendergast, AJ | en_US |
dc.date.accessioned | 2018-11-26T10:26:14Z | |
dc.date.available | 2018-11-16 | en_US |
dc.date.issued | 2018-12-20 | en_US |
dc.date.submitted | 2018-11-19T08:11:09.788Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/53288 | |
dc.description.abstract | Background: Micronutrient deficiencies may contribute to reduced oral vaccine immunogenicity in developing countries. We hypothesised that neonatal vitamin A supplementation (NVAS) would improve oral vaccine responses. Methods: We performed a cross-sectional study of infants recruited at birth to the Zimbabwe Vitamin A for Mothers and Babies (ZVITAMBO) trial, a randomised controlled trial of single, high-dose NVAS vs placebo conducted in Zimbabwe between 1997-2001. We measured poliovirus-specific IgA to type 1-3 polio strains by semiquantitative capture ELISA in cryopreserved plasma samples collected at 6 months of age. Results: A total of 181 infants fulfilled inclusion criteria, of whom 80 were randomised to NVAS and 101 to placebo. There were no significant differences in baseline characteristics between groups. At 6 months of age, median (IQR) vaccine titres for infants randomised to NVAS vs placebo were 932 (421-3001) vs 1774 (711-5431) for Sabin-1 (p=0.04); 1361 (705-3402) vs 2309 (1081-4283) for Sabin-2 (p=0.15); and 1584 (796-4216) vs 2260 (996-5723) for Sabin-3 (p=0.14), respectively. After adjusting for breast feeding status, birth weight, season and infant sex in a linear regression model, there was only weak evidence of difference in log mean titres between vitamin A and placebo groups for Sabin-1 (p=0.08) and no evidence of difference in log mean titres for Sabin-2 and Sabin-3. Conclusions: NVAS did not augment oral polio vaccine responses in Zimbabwean infants. Further research is required to understand the impact of NVAS on responses to other oral vaccines. The trial is registered with clinicaltrials.gov identifier: NCT00198718. | en_US |
dc.description.sponsorship | The ZVITAMBO trial was supported by the Canadian International Development Agency (CIDA) (R/C Project 690/M3688), United States Agency for International Development (USAID) (cooperative agreement number HRN-A-00-97-00015-00 between Johns Hopkins University and the Office of Health and Nutrition – USAID) and a grant from the Bill and Melinda Gates Foundation, Seattle WA. Additional funding was received from the SARA Project, which is operated by the Academy for Educational Development, Washington DC and is funded by USAID’s Bureau for Africa, Office of Sustainable Development under the terms of Contract AOT-C-00-99-00237-00, the Rockefeller Foundation (NY, NY) and BASF (Ludwigshafen, Germany). This current study was supported by the Sanitation & Hygiene Applied Research for Equity (SHARE) Consortium and Barts Charity (grant number 212563 to JAC). JAC (Grant 201293/Z/16/Z) and AJP (Grant 108065/Z/15/Z) are supported by the Wellcome Trust. | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Trans R Soc Trop Med Hyg | en_US |
dc.rights | This is a pre-copyedited, author-produced version of an article accepted for publication in Transactions of The Royal Society of Tropical Medicine and Hygiene, following peer review. The version of record: James A Church, Sandra Rukobo, Margaret Govha et al.; Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants, Transactions of The Royal Society of Tropical Medicine and Hygiene, try126, https://doi.org/10.1093/trstmh/try126 is available online at: https://doi.org/10.1093/trstmh/try126. | |
dc.title | Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1093/trstmh/try126 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30576507 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2018-11-19 | en_US |
qmul.funder | The impact of the intestinal environment on the immunogenicity of oral vaccines in Zimbabwean infants::Wellcome Trust | en_US |