Hypertension genomics and cardiovascular prevention.
Volume
6
Pagination
291 - ?
DOI
10.21037/atm.2018.06.34
Journal
Ann Transl Med
Issue
ISSN
2305-5839
Metadata
Show full item recordAbstract
Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. In light of the new knowledge from the largest cardiovascular GWAS to date, we review the potential impact of genomics on discovering potential drug targets, risk stratification with genetic risk scores, drug selection with pharmacogenetics, and exploring insights provided by gene-environment interactions.