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dc.contributor.authorGünther, Ten_US
dc.contributor.authorTulipano, Gen_US
dc.contributor.authorDournaud, Pen_US
dc.contributor.authorBousquet, Cen_US
dc.contributor.authorCsaba, Zen_US
dc.contributor.authorKreienkamp, H-Jen_US
dc.contributor.authorLupp, Aen_US
dc.contributor.authorKorbonits, Men_US
dc.contributor.authorCastaño, JPen_US
dc.contributor.authorWester, H-Jen_US
dc.contributor.authorCuller, Men_US
dc.contributor.authorMelmed, Sen_US
dc.contributor.authorSchulz, Sen_US
dc.date.accessioned2018-10-25T16:54:15Z
dc.date.issued2018-10en_US
dc.date.submitted2018-10-11T23:27:00.071Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/49064
dc.description.abstractSomatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G protein-coupled receptors (GPCRs) called somatostatin receptor (SST)1-5. These five receptors share common structural features and signaling mechanisms but differ in their cellular and subcellular localization and mode of regulation. SST2 and SST5 receptors have evolved as primary targets for pharmacological treatment of pituitary adenomas and neuroendocrine tumors. In addition, SST2 is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions. This review article summarizes findings published in the last 25 years on the physiology, pharmacology, and clinical applications related to SSTs. We also discuss potential future developments and propose a new nomenclature.en_US
dc.format.extent763 - 835en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofPharmacol Reven_US
dc.rightsThis is an open access article distributed under the CC BY Attribution 4.0 International license.
dc.subjectAnimalsen_US
dc.subjectGene Expression Regulationen_US
dc.subjectHumansen_US
dc.subjectLigandsen_US
dc.subjectProtein Conformationen_US
dc.subjectProtein Transporten_US
dc.subjectReceptors, Somatostatinen_US
dc.subjectSignal Transductionen_US
dc.subjectTerminology as Topicen_US
dc.titleInternational Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.en_US
dc.typeArticle
dc.rights.holder© 2018 The Author(s).
dc.identifier.doi10.1124/pr.117.015388en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30232095en_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume70en_US


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