dc.contributor.advisor | (c) 2018 James A Church. | |
dc.contributor.author | Church, JA | en_US |
dc.contributor.author | Parker, EP | en_US |
dc.contributor.author | Kosek, MN | en_US |
dc.contributor.author | Kang, G | en_US |
dc.contributor.author | Grassly, NC | en_US |
dc.contributor.author | Kelly, P | en_US |
dc.contributor.author | Prendergast, AJ | en_US |
dc.date.accessioned | 2018-07-09T13:56:51Z | |
dc.date.available | 2018-03-26 | en_US |
dc.date.issued | 2018-07 | en_US |
dc.date.submitted | 2018-06-29T07:22:40.770Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/41888 | |
dc.description.abstract | Oral vaccines significantly underperform in low-income countries. One possible contributory factor is environmental enteric dysfunction (EED), a subclinical disorder of small intestinal structure and function among children living in poverty. Here, we review studies describing oral vaccine responses and EED. We identified eight studies evaluating EED and oral vaccine responses. There was substantial heterogeneity in study design and few consistent trends emerged. Four studies reported a negative association between EED and oral vaccine responses; two showed no significant association; and two described a positive correlation. Current evidence is therefore insufficient to determine whether EED contributes to oral vaccine underperformance. We identify roadblocks in the field and future research needs, including carefully designed studies those can investigate this hypothesis further. | en_US |
dc.description.sponsorship | JAC (Grant 201293/Z/16/Z) and AJP (Grant 108065/Z/15/Z) are funded by the Wellcome Trust. JAC and AJP also received funding from DfID via the Sanitation & Hygiene Applied Research for Equity (SHARE) Consortium. | en_US |
dc.format.extent | 1055 - 1070 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Future Microbiol | en_US |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution License 4.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | EED | en_US |
dc.subject | infant | en_US |
dc.subject | oral vaccine | en_US |
dc.subject | Adaptive Immunity | en_US |
dc.subject | Administration, Oral | en_US |
dc.subject | Adolescent | en_US |
dc.subject | Asymptomatic Diseases | en_US |
dc.subject | Child | en_US |
dc.subject | Child, Preschool | en_US |
dc.subject | Environmental Exposure | en_US |
dc.subject | Gastrointestinal Diseases | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant | en_US |
dc.subject | Infant, Newborn | en_US |
dc.subject | Intestine, Small | en_US |
dc.subject | Poverty | en_US |
dc.subject | Vaccines | en_US |
dc.title | Exploring the relationship between environmental enteric dysfunction and oral vaccine responses. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.2217/fmb-2018-0016 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29926747 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 13 | en_US |
qmul.funder | The impact of the intestinal environment on the immunogenicity of oral vaccines in Zimbabwean infants::Wellcome Trust | en_US |
qmul.funder | The impact of the intestinal environment on the immunogenicity of oral vaccines in Zimbabwean infants::Wellcome Trust | en_US |