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dc.contributor.advisor(c) 2018 James A Church.
dc.contributor.authorChurch, JAen_US
dc.contributor.authorParker, EPen_US
dc.contributor.authorKosek, MNen_US
dc.contributor.authorKang, Gen_US
dc.contributor.authorGrassly, NCen_US
dc.contributor.authorKelly, Pen_US
dc.contributor.authorPrendergast, AJen_US
dc.date.accessioned2018-07-09T13:56:51Z
dc.date.available2018-03-26en_US
dc.date.issued2018-07en_US
dc.date.submitted2018-06-29T07:22:40.770Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/41888
dc.description.abstractOral vaccines significantly underperform in low-income countries. One possible contributory factor is environmental enteric dysfunction (EED), a subclinical disorder of small intestinal structure and function among children living in poverty. Here, we review studies describing oral vaccine responses and EED. We identified eight studies evaluating EED and oral vaccine responses. There was substantial heterogeneity in study design and few consistent trends emerged. Four studies reported a negative association between EED and oral vaccine responses; two showed no significant association; and two described a positive correlation. Current evidence is therefore insufficient to determine whether EED contributes to oral vaccine underperformance. We identify roadblocks in the field and future research needs, including carefully designed studies those can investigate this hypothesis further.en_US
dc.description.sponsorshipJAC (Grant 201293/Z/16/Z) and AJP (Grant 108065/Z/15/Z) are funded by the Wellcome Trust. JAC and AJP also received funding from DfID via the Sanitation & Hygiene Applied Research for Equity (SHARE) Consortium.en_US
dc.format.extent1055 - 1070en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofFuture Microbiolen_US
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License 4.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/
dc.subjectEEDen_US
dc.subjectinfanten_US
dc.subjectoral vaccineen_US
dc.subjectAdaptive Immunityen_US
dc.subjectAdministration, Oralen_US
dc.subjectAdolescenten_US
dc.subjectAsymptomatic Diseasesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectEnvironmental Exposureen_US
dc.subjectGastrointestinal Diseasesen_US
dc.subjectHumansen_US
dc.subjectInfanten_US
dc.subjectInfant, Newbornen_US
dc.subjectIntestine, Smallen_US
dc.subjectPovertyen_US
dc.subjectVaccinesen_US
dc.titleExploring the relationship between environmental enteric dysfunction and oral vaccine responses.en_US
dc.typeArticle
dc.identifier.doi10.2217/fmb-2018-0016en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29926747en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume13en_US
qmul.funderThe impact of the intestinal environment on the immunogenicity of oral vaccines in Zimbabwean infants::Wellcome Trusten_US
qmul.funderThe impact of the intestinal environment on the immunogenicity of oral vaccines in Zimbabwean infants::Wellcome Trusten_US


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