Protein kinases involved in epidermal barrier formation: The AKT family and other animals.
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Volume
27
Pagination
892 - 900
DOI
10.1111/exd.13696
Journal
Exp Dermatol
Issue
Metadata
Show full item recordAbstract
Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epidermal barrier function is initiated during embryonic development and is then maintained throughout life and restored after injury. A variety of interrelated processes are required for the formation of a stratified epidermis, and how these processes are both temporally and spatially regulated has long been an aspect of dermatological research. In this review, we describe the roles of multiple protein kinases in the regulation of processes required for epidermal barrier formation.