Cell and Molecular Biology
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Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models
(Springer Nature, 2024-02-19)RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been associated with several psychiatric conditions, but the ... -
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics
(Rockefeller University Press, 2023-03-02)Time-lapse microscopy movies have transformed the study of subcellular dynamics. However, manual analysis of movies can introduce bias and variability, obscuring important insights. While automation can overcome such ... -
Olfactory receptor pseudo-pseudogenes
(Springer Nature, 2016-11-03) -
Survey of Global Genetic Diversity Within the Drosophila Immune System
(Oxford University Press (OUP), 2017-01-01) -
Global Diversity Lines–A Five-Continent Reference Panel of Sequenced<i>Drosophila melanogaster</i>Strains
(Oxford University Press (OUP), 2015-04-01)<jats:title>Abstract</jats:title><jats:p>Reference collections of multiple Drosophila lines with accumulating collections of “omics” data have proven especially valuable for the study of population genetics and complex ... -
Evidence for the fixation of gene duplications by positive selection in Drosophila.
(2016-06)Gene duplications play a key role in the emergence of novel traits and in adaptation. But despite their centrality to evolutionary processes, it is still largely unknown how new gene duplicates are initially fixed within ... -
Open questions: Tackling Darwin’s “instincts”: the genetic basis of behavioral evolution
(Springer Science and Business Media LLC, 2017-12) -
Demographic History of the Human Commensal Drosophila melanogaster.
(2019-03-01)The cohabitation of Drosophila melanogaster with humans is nearly ubiquitous. Though it has been well established that this fly species originated in sub-Saharan Africa, and only recently has spread globally, many details ... -
An ERK1/2-driven RNA-binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene
(EMBO Press, 2023-04-11)Oncogenic RAS signaling reprograms gene expression through both transcriptional and post‐transcriptional mechanisms. While transcriptional regulation downstream of RAS is relatively well characterized, how RAS post‐trans ... -
Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion.
(2023)Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) ... -
Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n-3 DPA.
(2023-10-25)The methyl ester of resolvin D5n-3 DPA, a lipid mediator biosynthesized from the omega-3 fatty acid n-3 docosapentaenoic acid, was stereoselectively prepared in 8% yield over 12 steps (longest linear sequence). The key ...