| dc.contributor.author | Mosqueira, D | en_US |
| dc.contributor.author | Mannhardt, I | en_US |
| dc.contributor.author | Bhagwan, JR | en_US |
| dc.contributor.author | Lis-Slimak, K | en_US |
| dc.contributor.author | Katili, P | en_US |
| dc.contributor.author | Scott, E | en_US |
| dc.contributor.author | Hassan, M | en_US |
| dc.contributor.author | Prondzynski, M | en_US |
| dc.contributor.author | Harmer, SC | en_US |
| dc.contributor.author | Tinker, A | en_US |
| dc.contributor.author | Smith, JGW | en_US |
| dc.contributor.author | Carrier, L | en_US |
| dc.contributor.author | Williams, PM | en_US |
| dc.contributor.author | Gaffney, D | en_US |
| dc.contributor.author | Eschenhagen, T | en_US |
| dc.contributor.author | Hansen, A | en_US |
| dc.contributor.author | Denning, C | en_US |
| dc.date.accessioned | 2018-06-05T10:59:55Z | |
| dc.date.available | 2018-04-11 | en_US |
| dc.date.issued | 2018-11-14 | en_US |
| dc.date.submitted | 2018-05-24T11:37:36.472Z | |
| dc.identifier.issn | 0195-668X | en_US |
| dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/39283 | |
| dc.description.sponsorship | British Heart Foundation [grant numbers
SP/15/9/31605, RG/15/6/31436, PG/14/59/31000, RG/14/1/30588, RM/13/
30157, P47352/CRM]; Britain Israel Research and Academic Exchange
Partnership [04BX14CDLG]; the Medical Research Council [grant number
MR/M017354/1: MICA: Development of Metrics and Quality
Standards for Scale up of Human Pluripotent Stem Cells]; the National
Centre for the Replacement, Refinement & Reduction of Animals in
Research [grant numbers CRACK-IT:35911-259146, NC/K000225/1]; the
German Research Foundation [DFG-Es-88/12-1, HA3423/5-1]; European
Research Council [ERC-AG-IndivuHeart]; European Commission [FP7-
Biodesign]; German Centre for Cardiovascular Research (DZHK) and the
German Ministry of Education and Research, the Freie und Hansestadt
Hamburg. | en_US |
| dc.format.extent | 3879 - + | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | EUROPEAN HEART JOURNAL | en_US |
| dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| dc.subject | Hypertrophic cardiomyopathy | en_US |
| dc.subject | Disease modeling | en_US |
| dc.subject | CRISPR/Cas9 | en_US |
| dc.subject | Genome-edited human pluripotent stem cell | en_US |
| dc.subject | cardiomyocytes | en_US |
| dc.subject | R453C-bMHC | en_US |
| dc.title | CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy | en_US |
| dc.type | Article | |
| dc.rights.holder | (c) The Author(s) 2018. | |
| dc.identifier.doi | 10.1093/eurheartj/ehy249 | en_US |
| pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000453397400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
| pubs.issue | 43 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published | en_US |
| pubs.volume | 39 | en_US |
