Centre for Endocrinology: Recent submissions
Now showing items 321-340 of 560
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Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism.
(2018)Early-onset acromegaly causing gigantism is often associated with aryl-hydrocarbon-interacting receptor protein (AIP) mutation, especially if there is a positive family history. A15y male presented with tiredness and visual ... -
Stability and Turnover of the ACTH Receptor Complex
(2019-07-26) -
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.
(2019-10-11)RATIONALE: Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A2, both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate ... -
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo
(Springer Science and Business Media LLC, 2009-10) -
Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells
(Rockefeller University Press, 2015-08-24)<jats:p>Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become ... -
The Genetic Basis of Delayed Puberty.
(2019)Delayed pubertal onset has many etiologies, but on average two-thirds of patients presenting with late puberty have self-limited (or constitutional) delayed puberty. Self-limited delayed puberty often has a strong familial ... -
Rings and Bricks: Expression of Cohesin Components is Dynamic during Development and Adult Life.
(2018-02-01)Cohesin complex components exert fundamental roles in animal cells, both canonical in cell cycle and non-canonical in gene expression regulation. Germline mutations in genes coding for cohesins result in developmental ... -
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
<jats:p>Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking ... -
The kindlin family: functions, signaling properties and implications for human disease
(The Company of Biologists, 2016-01-01) -
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
(Springer Science and Business Media LLC, 2014-04) -
ACTH signalling and adrenal development: lessons from mouse models.
(2019-07)The melanocortin-2-receptor (MC2R), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC2R in adrenal physiology is exemplified by the condition familial ...