Centre for Endocrinology: Recent submissions
Now showing items 281-300 of 560
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Glucocorticoid replacement therapies: past, present and future.
(2019-10)Since the original description of adrenal insufficiency by Thomas Addison in 1855, there has been an exponential growth in the understanding of adrenal gland biology and its role in the hypothalamic-pituitary-adrenal axis. ... -
Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness.
(BioScientifica [, 2019-12)Tumour-associated fibroblasts (TAFs) are key elements of the tumour microenvironment, but their role in pituitary neuroendocrine tumours (PitNETs) has been little explored. We hypothesised that TAF-derived cytokines may ... -
Pseudoacromegaly: A Differential Diagnostic Problem for Acromegaly With a Genetic Solution.
(2017-08-01)Acromegaly is usually not a difficult condition to diagnose once the possibility of this disease has been raised. However, a few conditions present with some aspects of acromegaly or gigantism but without growth hormone ... -
A Novel Stem Cell Model for the Triple a Syndrome
(Karger, 2018)Meeting abstract FC1.6 from 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE) -
Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System
(Frontiers Media, 2019-11-08)The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, ... -
SGPL1 Missense Mutation in an Infant with Primary Adrenal Insufficiency (PAI), Congenital Nephrotic Syndrome, Primary Hypothyroidism and Gonadal Failure
(2018)Meeting abstract from 57th Annual ESPE Conference, Athens, Greece, 27 - 29 Sep 2018. -
GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients.
(Bioscientifica Ltd, 2020-03-01)OBJECTIVES: The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity. We investigated whether transcript heterogeneity (6Ψ-GHR to ... -
Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review.
(2020-02)Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system. ... -
Pediatric Parathyroid Carcinoma: A Case Report and Review of the Literature.
(2019-12-01)Primary hyperparathyroidism (PHPT) is a rare endocrine disease in the pediatric population. Sporadic parathyroid adenomas remain the most common cause of pediatric PHPT. Parathyroid carcinoma (PC) is an extremely rare cause ...