Browsing Centre for Endocrinology by Subject "gigantism"
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Genetics of Acromegaly and Gigantism.
(MDPI, 2021-03-29)Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined pituitary tumour type. This is true both for germline and somatic mutations. Germline mutations occur in several known genes (AIP, ... -
Phosphodiesterases and cAMP pathway in pituitary diseases
(Frontiers Media SA, 2019-03-19)© 2019 Bizzi, Bolger, Korbonits and Ribeiro-Oliveira. Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different ... -
Sporadic pituitary adenomas: the role of germline mutations and recommendations for genetic screening.
(2017-03)INTRODUCTION: Although most pituitary adenomas occur sporadically, these common tumors can present in a familial setting in approximately 5% of cases. Germline mutations in several genes with autosomal dominant (AIP, MEN1, ... -
Tall stature and gigantism in adult patients with acromegaly.
(2024-03-02)OBJECTIVES: Increased height in patients with acromegaly could be a manifestation of growth hormone (GH) excess before epiphysis closure. The aim of this study was to evaluate the relationship between the height of adult ...