Browsing Centre for Endocrinology by Author "Zent, R"
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Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
Theodosiou, M; Widmaier, M; Böttcher, RT; Rognoni, E; Veelders, M; Bharadwaj, M; Lambacher, A; Austen, K; Müller, DJ; Zent, R<jats:p>Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking ...