Browsing Centre for Endocrinology by Author "Zennaro, M-C"
Now showing items 1-4 of 4
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CTNNB1-Mutant Aldosterone-Producing Adenomas With Somatic Mutations of GNA11/GNAQ Have Distinct Phenotype and Genotype
Zhou, J; Boulkroun, S; Cabrera, CP; Azizan, EAB; Fernandes-Rosa, F; Cottrell, E; Argentesi, G; Wu, X; O’Toole, S; Marker, A (Oxford University Press, 2021-05-03) -
SAT-224 Recurrent Co-Driver Mutation in CTNNB1-Mutant Aldosterone-producing Adenomas (APA), Causing Reversible Hypertension in Puberty, Pregnancy or Menopause
Zhou, J; Cabrera, CP; Azizan, EAB; Fernandes-Rosa, F; Cottrell, E; Amar, L; Argentesi, G; Wu, X; Marker, A; Jordan, S (2020-05-08)Abstract SAT-224 from ENDO 2020 Abstracts Scheduled for the Annual Meeting of the Endocrine Society – March 28 – 31, 2020 - San Francisco, California (Cancelled). Background: Three patients with a syndrome of LH/HCG-activated ... -
Somatic Mutations of GNA11 and GNAQ in CTNNB1-Mutant Aldosterone-Producing Adenomas Increases Aldosterone and Aldosterone Synthase (CYP11B2)
Azizan, EAB; Zhou, J; Cabrera, CP; Fernandes-Rosa, FL; Boulkroun, S; Argentesi, G; Cottrell, E; Amar, L; Wu, X; Marker, A (2021-05-03) -
Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.
Zhou, J; Azizan, EAB; Cabrera, CP; Fernandes-Rosa, FL; Boulkroun, S; Argentesi, G; Cottrell, E; Amar, L; Wu, X; O'Toole, S (Nature Research, 2021-08-12)Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement ...