Browsing Centre for Endocrinology by Author "Sahdev, A"
Now showing items 1-9 of 9
-
An analysis of surveillance screening for SDHB-related disease in childhood and adolescence.
Tufton, N; Shapiro, L; Sahdev, A; Kumar, AV; Martin, L; Drake, WM; Akker, SA; Storr, HL (2019-03-01)Objective Phaeochromocytomas (PCC) and paragangliomas (PGL) are rare in children. A large proportion of these are now understood to be due to underlying germline mutations. Here we focus on succinate dehydrogenase subunit ... -
Can subunit-specific phenotypes guide surveillance imaging decisions in asymptomatic SDH mutation carriers?
Tufton, N; Sahdev, A; Drake, WM; Akker, SA (John Wiley & Sons Ltd, 2019-11-28)Objective With the discovery that familial phaeochromocytoma and paraganglioma syndrome can be caused by mutations in each subunit of the succinate dehydrogenase enzyme (SDH), has come the recognition that mutations in ... -
Diffusion‐weighted imaging (DWI) highlights SDHB ‐related tumours: A pilot study
Tufton, N; White, G; Drake, WM; Sahdev, A; Akker, SA (John Wiley & Sons Ltd, 2019-04-11)OBJECTIVE: There is consensus that asymptomatic carriers of SDHB mutations should undergo periodic surveillance imaging. MRI has the advantage of avoiding radiation exposure but its sensitivity and specificity for detecting ... -
GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.
Srirangam Nadhamuni, V; Iacovazzo, D; Evanson, J; Sahdev, A; Trouillas, J; McAndrew, L; R Kurzawinski, T; Bryant, D; Hussain, K; Bhattacharya, S (2021-06-01)Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour ... -
Low-grade Cortisol Cosecretion Has Limited Impact on ACTH-stimulated AVS Parameters in Primary Aldosteronism.
O'Toole, SM; Sze, W-CC; Chung, T-T; Akker, SA; Druce, MR; Waterhouse, M; Pitkin, S; Dawnay, A; Sahdev, A; Matson, M (2020-10-01)CONTEXT: In primary aldosteronism, cosecretion of cortisol may alter cortisol-derived adrenal venous sampling indices. OBJECTIVE: To identify whether cortisol cosecretion in primary aldosteronism alters adrenal venous ... -
Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial.
Pernicova, I; Kelly, S; Ajodha, S; Sahdev, A; Bestwick, JP; Gabrovska, P; Akanle, O; Ajjan, R; Kola, B; Stadler, M (2020-04)BACKGROUND: An urgent need to reduce the metabolic side-effects of glucocorticoid overexposure has been recognised, as glucocorticoid excess can lead to Cushing's syndrome, which is associated with high morbidity. We aimed ... -
Outcomes of annual surveillance imaging in an adult and paediatric cohort of succinate dehydrogenase B mutation carriers
Tufton, N; Shapiro, L; Srirangalingam, U; Richards, P; Sahdev, A; Kumar, AV; McAndrew, L; Martin, L; Berney, D; Monson, J (2017-02) -
Radiological Surveillance Screening in Asymptomatic Succinate Dehydrogenase Mutation Carriers
Tufton, N; Sahdev, A; Akker, SA (The Endocrine Society, 2017-07-01) -
Succinate Dehydrogenase B (SDHB)-Associated Bladder Paragangliomas.
Srirangalingam, U; Banerjee, A; Patki, P; Peters, J; George, E; Chew, SL; Kumar, VKA; Korbonits, M; Waterhouse, M; Druce, MR (2017-02)