Browsing Centre for Endocrinology by Author "Ichimura, T"
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T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
Okoye, I; Wang, L; Pallmer, K; Richter, K; Ichimura, T; Haas, R; Crouse, J; Choi, O; Heathcote, D; Lovo, E (2015-04-16)Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion ...