Browsing Centre for Endocrinology by Author "Backman, S"
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Somatic Mutations of GNA11 and GNAQ in CTNNB1-Mutant Aldosterone-Producing Adenomas Increases Aldosterone and Aldosterone Synthase (CYP11B2)
Azizan, EAB; Zhou, J; Cabrera, CP; Fernandes-Rosa, FL; Boulkroun, S; Argentesi, G; Cottrell, E; Amar, L; Wu, X; Marker, A (2021-05-03) -
Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.
Zhou, J; Azizan, EAB; Cabrera, CP; Fernandes-Rosa, FL; Boulkroun, S; Argentesi, G; Cottrell, E; Amar, L; Wu, X; O'Toole, S (Nature Research, 2021-08-12)Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement ...