Search
Now showing items 1-5 of 5
Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.
(2018-07-01)
Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning toward the function of these association signals, ...
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
(Nature Research (part of Springer Nature), 2018-04-09)
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated ...