Browsing William Harvey Research Institute by Subject "2-hydroxyglutarate"

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    • 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. 

      Fitzpatrick, SF; Lambden, S; Macias, D; Puthucheary, Z; Pietsch, S; Mendil, L; McPhail, MJW; Johnson, RS (Frontiers Media, 2020-03-03)
      The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) ...