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Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.
(Oxford University Press, 2019-01-01)
Objective: Immune activation is associated with morbidity and mortality during human immunodeficiency virus (HIV) infection, despite receipt of antiretroviral therapy (ART). We investigated whether microbial translocation ...
Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis
(Wolters Kluwer Health, Inc, 2016-11-28)
Objective:
To evaluate whether cotrimoxazole prophylaxis prevents common skin conditions in HIV-infected children.
Design:
Open-label randomized controlled trial of continuing versus stopping daily cotrimoxazole ...
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial.
(Oxford University Press, 2018-03-04)
Background: Severely immunocompromised human immunodeficiency virus (HIV)-infected individuals have high mortality shortly after starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ...
Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy
(Oxford University Press, 2016-05-18)
Background. Identifying determinants of morbidity and mortality may help target future interventions for human immunodeficiency virus (HIV)–infected children.
Methods. CD4+ T-cell count, HIV viral load, and levels of ...
Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants.
(2017-11-02)
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe ...
Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the preantiretroviral therapy era
(Lippincott, Williams & Wilkins, 2016-09-24)
Objectives: To describe the head growth of children according to maternal and child
HIV infection status.
Design: Longitudinal analysis of head circumference data from 13 647 children
followed from birth in the ZVITAMBO ...
The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa.
(Oxford University Press, 2019-10-23)
Cotrimoxazole prophylaxis reduces morbidity and mortality among people living
with human immunodeficiency virus
(HIV) in sub-Saharan Africa, regardless
of age, degree of immunosuppression,
disease stage, or duration ...