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Coexistent faecal incontinence and constipation: A cross-sectional study of 4027 adults undergoing specialist assessment.
(2020-10)
Background: In contrast to paediatric and geriatric populations, faecal incontinence and constipation in adults are generally considered separate entities. This may be incorrect. Methods: Cross-sectional study of consecutive ...
Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.
(2021-02-01)
BACKGROUND: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians ...
Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres providing new mechanistic insights.
(2020-12-20)
AIM: Conventional parameters (anal resting and squeeze pressures) measured with anorectal manometry (ARM) fail to identify anal sphincter dysfunction in many patients with low anterior resection syndrome (LARS). We assessed ...
Systematic Characterization of Defecographic Abnormalities in a Consecutive Series of 827 Patients with Chronic Constipation.
(2021-04-05)
BACKGROUND: Barium defecography can assess structural and functional abnormalities in patients with chronic constipation. OBJECTIVE: To determine the prevalence of individual and overlapping defecographic findings in this ...
Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells
(BMJ, 2021-06-03)
Objective Colonic enteroendocrine cells (EECs) store and release potent anorectic hormones that are key regulators of satiety. EECs express multiple nutrient sensing receptors, particularly for medium-chain fatty acids ...
Redundancy in the International Anorectal Physiology Working Group Manometry Protocol: A Diagnostic Accuracy Study in Fecal Incontinence.
(Springer, 2021-05-03)
BACKGROUND: Anorectal manometry (ARM) is essential for identifying sphincteric dysfunction. The International Anorectal Physiology Working Group (IAPWG) protocol and London Classification provide a standardized format for ...
Clinical Impact of Rectal Hyposensitivity: A Cross-Sectional Study of 2,876 Patients With Refractory Functional Constipation.
(Lippincott, Williams & Wilkins, 2021-04-01)
INTRODUCTION: Normal bowel function requires intact sensory pathways. Diminished rectal sensation (rectal hyposensitivity [RH]) is associated with constipation, although its clinical importance remains unclear. METHODS: ...
Slow-transit constipation and criteria for colectomy: a cross-sectional study of 1568 patients.
(2021-05-07)
BACKGROUND: Colectomy remains a treatment option for a minority of patients with slow-transit constipation (STC) refractory to conservative treatment. However careful patient selection is essential to maximize benefits and ...
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
(2021)
Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the ...