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Now showing items 61-70 of 175
Month of Birth and Thymic Output
(2013-04)
Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy.
(2015-01-28)
Matrix metalloproteinase-9 (MMP-9) plays an important role in both physiological and pathological processes. This enzyme is a peripheral biomarker of neuroinflammation in multiple sclerosis (MS), a chronic autoimmune disease ...
The problem with repurposing: Is there really an alternative to Big Pharma for developing new drugs for multiple sclerosis?
(2015-01-01)
©2014 Elsevier B.V. All rights reserved. If it is not feasible to develop licensed drugs to the stage that they can actually be prescribed for a new indication, can we justify, either ethically or economically, the undertaking ...
Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
(Public Library of Science, 2013-09-20)
Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into cerebrospinal fluid has shown encouraging results as a ...
Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study
(BMJ Publishing Group Ltd, 2015-04-13)
Objective To investigate the role of longitudinal
plasma neurofilament heavy chain protein (NfH) levels
as an indicator of clinical progression and survival in
amyotrophic lateral sclerosis (ALS).
Methods A cross-sectional ...
Increased expression of colony-stimulating factor-1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss.
(2018-10)
Microglia contribute to pathophysiology at all stages of multiple sclerosis. Colony-stimulating factor-1 (CSF1) is crucial for microglial proliferation and activation. In this study we measured the CSF1 levels and studied ...