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A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.
(2018-08)
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...
BCNTB bioinformatics: the next evolutionary step in the bioinformatics of breast cancer tissue banking.
(2018-01-04)
Here, we present an update of Breast Cancer Now Tissue Bank bioinformatics, a rich platform for the sharing, mining, integration and analysis of breast cancer data. Its modalities provide researchers with access to a ...
The Pancreatic Expression Database: 2018 update.
(2018-01-04)
The Pancreatic Expression Database (PED, http://www.pancreasexpression.org) continues to be a major resource for mining pancreatic -omics data a decade after its initial release. Here, we present recent updates to PED and ...
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
(Elsevier/Science Direct, 2018-02-27)
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...
'Multi-omic' data analysis using O-miner
(2019-01)