Browsing Barts Cancer Institute by Subject "systems biology"
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Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.
(eLife Sciences Publications Ltd, 2020-03-30)The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in ...