Browsing Barts Cancer Institute by Subject "adaptive hypoxic response"

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    • A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. 

      Foxler, DE; Bridge, KS; Foster, JG; Grevitt, P; Curry, S; Shah, KM; Davidson, KM; Nagano, A; Gadaleta, E; Rhys, HI (2018-08)
      The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...