Browsing Barts Cancer Institute by Subject "Ubiquitination"
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DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
(2007-12-31)In addition to their well-known function in apoptosis, caspases are also important in several nonapoptotic processes. How caspase activity is restrained and shut down under such nonapoptotic conditions remains unknown. ... -
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
(2017-12)BACKGROUND & AIMS: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors such as gastrinomas, characterized by ...