Browsing Barts Cancer Institute by Subject "Tumor Suppressor Proteins"
Now showing items 1-2 of 2
-
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.
(2017-11-13)Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic editing tool, ... -
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation.
(Impact Journals, 2013-10-13)TSC2 (Tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. TSC2 protein complexes with ...