Browsing Barts Cancer Institute by Subject "Transcription, Genetic"
Now showing items 1-2 of 2
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A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation.
(Impact Journals, 2013-10-13)TSC2 (Tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. TSC2 protein complexes with ... -
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.
(2015-08-27)Castration-resistant (CR) prostate cancer (PCa) partly arises due to persistence of androgen receptor (AR) transcriptional activity in the absence of cognate ligand. An emerging mechanism underlying the CRPCa phenotype and ...