Browsing Barts Cancer Institute by Subject "Models, Biological"
Now showing items 1-4 of 4
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Cdk7: open questions beyond the prevailing model.
(2012-10-01) -
Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny.
(2017-10)Current dogma asserts that mammalian lifelong blood production is established by a small number of blood progenitors. However, this model is based on assays that require the disruption, transplantation and/or culture of ... -
PKCɛ switches Aurora B specificity to exit the abscission checkpoint.
(2016-12-22)The 'NoCut', or Aurora B abscission checkpoint can be activated if DNA is retained in the cleavage furrow after completion of anaphase. Checkpoint failure leads to incomplete abscission and a binucleate outcome. These ... -
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.
(2015-08-27)Castration-resistant (CR) prostate cancer (PCa) partly arises due to persistence of androgen receptor (AR) transcriptional activity in the absence of cognate ligand. An emerging mechanism underlying the CRPCa phenotype and ...