Browsing Barts Cancer Institute by Subject "Adenocarcinoma"
Now showing items 1-4 of 4
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Insights Into the Pathophysiology of Esophageal Adenocarcinoma.
(2018-01)Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic ... -
Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.
(2023-07-15)A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping ... -
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
(2022-04-08)Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed ... -
Repeated negative biopsies in isolated high-grade cystic duct dysplasia with progression to adenocarcinoma.
(2014-09)Cystic and bile duct dysplasia is a rare histological finding, especially when found in the absence of an underlying malignancy. We report a patient who presented with jaundice and weight loss. Clinical and cytological ...