Browsing Barts Cancer Institute by Title
Now showing items 964-983 of 1159
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scMoMaT jointly performs single cell mosaic integration and multi-modal bio-marker detection
(Nature Research, 2023-01-24)Single cell data integration methods aim to integrate cells across data batches and modalities, and data integration tasks can be categorized into horizontal, vertical, diagonal, and mosaic integration, where mosaic ... -
Seminoma and dysgerminoma: evidence for alignment of clinical trials and de-escalation of systemic chemotherapy.
(2023)Malignant germ cell tumours are a group of rare cancers whose incidence peaks in late adolescence and early adulthood. Dysgerminomas of the ovary and seminomas of the testis are analogous diseases, but seminomas have a ... -
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.
(2023-10-27)KMT2A-rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization and chemical interrogation identified kinases as key drivers of survival ...