Browsing Barts Cancer Institute by Title
Now showing items 880-899 of 1159
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Rac1 Deletion Causes Thymic Atrophy
(2011-04-29) -
A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway.
(2012)Previously described methods for the combined analysis of common and rare variants have disadvantages such as requiring an arbitrary classification of variants or permutation testing to assess statistical significance. ... -
Rare benign mixed tumour of the upper lip: A case report.
(2015-12)BACKGROUND: Chondroid syringomas (CS) are rare benign mixed tumours. Clinical differentiation can be misleading due to the silent presentation, with only histopathological findings confirming the diagnosis. CASE REPORT: A ... -
Rarity: Discovering rare cell populations from single-cell imaging data
(Oxford University Press, 2023-12-13)MOTIVATION: Cell type identification plays an important role in the analysis and interpretation of single-cell data and can be carried out via supervised or unsupervised clustering approaches. Supervised methods are best ... -
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent.
(2017-11-09)Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration of IL-12 precludes its clinical application. ... -
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas.
(2022-04-08)Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed ... -
Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
(Nature Publishing, 2020-01-20)Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics ... -
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
(2021-08)Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ... -
Recruitment, adherence, and retention of endometrial cancer survivors in a behavioural lifestyle programme: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomised pilot trial.
(2017-10-08)OBJECTIVE: Healthy eating and physical activity may help endometrial cancer survivors (ECS) improve their quality of life. However, most ECS do not meet the relevant guidelines. This pilot trial aimed to test the study ...