Browsing Barts Cancer Institute by Title
Now showing items 603-622 of 1159
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The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
(Springer Nature, 2019-03-28)Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in ... -
Mapping Rora expression in resting and activated CD4+ T cells.
(Public Library of Science, 2021-05-18)The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with ... -
MD-1 downregulation is associated with reduced cell surface CD180 expression in CLL
(Elsevier BV, 2024-06) -
Measures of genetic diversification in somatic tissues at bulk and single-cell resolution.
(eLife Sciences Publications, 2024-01-24)Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics ... -
Measuring cancer evolution from the genome
(2017-01) -
Measuring Clonal Evolution in Cancer with Genomics.
(2019-08-31)Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal ... -
Measuring single cell divisions in human cancers from multi-region sequencing data
(2019-02-25)Abstract Cancer is driven by complex evolutionary dynamics involving billions of cells. Increasing effort has been dedicated to sequence single tumour cells, but obtaining robust measurements remains challenging. Here we ... -
Measuring single cell divisions in human tissues from multi-region sequencing data.
(Nature Research (part of Springer Nature), 2020-02-25)Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in ... -
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
(2019-06-05)Abstract The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection ... -
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.
(eLife Sciences Publications Ltd, 2020-03-30)The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in ... -
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.
(2012-02-16)B-cell receptor and microenvironment-derived signals promote accumulation of chronic lymphocytic leukemia (CLL) cells through increased proliferation and/or decreased apoptosis. In this study, we investigated the regulation ... -
Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment.
(2023-06-05)BACKGROUND: The crosstalk between cancer and the tumour immune microenvironment (TIME) has attracted significant interest in the latest years because of its impact on cancer evolution and response to treatment. Despite ...