Browsing Barts Cancer Institute by Title
Now showing items 663-682 of 1165
-
Molecular characteristics of early-onset pancreatic ductal adenocarcinoma.
(2023-12-25)The median age of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis is 71 years; however, around 10% present with early-onset pancreatic cancer (EOPC), i.e., before age 50. The molecular mechanisms underlying ... -
Mosquito cellular immunity at single-cell resolution
(2020-08-28) -
Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology.
(2014-07-03)The distinct nature of acute lymphoblastic leukemia (ALL) in adults, evidenced by inferior treatment outcome and different genetic landscape, mandates specific studies of disease-initiating mechanisms. In this study, we ... -
The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function
(Rockefeller University Press, 2020-11-06) -
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
(Nature Research, 2023-05-08)Cancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis; however, its ... -
'Multi-omic' data analysis using O-miner
(2019-01) -
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia
(Springer Science and Business Media LLC, 2021-12)Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform ...