Browsing Barts Cancer Institute by Title
Now showing items 643-662 of 1159
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miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
(2019-04)Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, ... -
Mitotic catenation is monitored and resolved by a PKCε-regulated pathway.
(2014-12-08)Exit from mitosis is controlled by silencing of the spindle assembly checkpoint (SAC). It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and that residual catenation is resolved, ... -
The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data
(BioMed Central, 2020-11-17) -
Model-based tumor subclonal reconstruction
(2019)The vast majority of cancer next-generation sequencing data consist of bulk samples composed of mixtures of cancer and normal cells. To study tumor evolution, subclonal reconstruction approaches based on machine learning ... -
Modelling TGF beta R and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
(Cell Press, 2021-05-29) -
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
(Elsevier, 2021-05)In a multi-level ‘deconstruction’ of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim ... -
Modifying oncolytic viral therapy for pancreatic cancer
(2016-06-01) -
Molecular characteristics of early-onset pancreatic ductal adenocarcinoma.
(2023-12-25)The median age of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis is 71 years; however, around 10% present with early-onset pancreatic cancer (EOPC), i.e., before age 50. The molecular mechanisms underlying ...