Browsing Barts Cancer Institute by Title
Now showing items 406-425 of 1165
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Genetic and immune landscape evolution in MMR-deficient colorectal cancer.
(2023-11-15)Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote ... -
Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma.
(Ferrata Storti Foundation, 2020-04-09) -
Genetic screening for gynecological cancer: where are we heading?
(2016-01)The landscape of cancer genetics in gynecological oncology is rapidly changing. The traditional family history-based approach has limitations and misses >50% mutation carriers. This is now being replaced by population-based ... -
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
(Nature Publishing Group, 2017-12-01)Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide ... -
A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest
(Oxford University Press on behalf of Nucleic Acids Research, 2019-04-08) -
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia
(Nature Publishing Group, 2017-11-08)Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes ... -
Genomic and transcriptomic approaches towards the genetic improvement of an underutilised crops: The case of Bambara groundnut
(Makerere University, 2016-12-02)With the world population estimated to be nine billion by 2050, the need to exploit plant genetic diversity in order to increase and diversify global food supply, and minimise the over-reliance for food on a few staple ... -
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
(Springer Nature, 2017-04-20)Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical ... -
Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.
(2017-11-13)Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. ...