Browsing Barts Cancer Institute by Title
Now showing items 41-60 of 1159
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Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
(2022-01-10)Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. ... -
Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states
(Frontiers Media, 2024-04-02)Background: More than 700 million people worldwide suffer from diseases of the pancreas, such as diabetes, pancreatitis and pancreatic cancer. Often dysregulation of potassium (K+) channels, co-transporters and pumps can ... -
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
(Impact journals, 2015-10-07)Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ... -
Androgen-dependent alternative mRNA isoform expression in prostate cancer cells.
(F1000Research, 2018-08-03)Background: Androgen steroid hormones are key drivers of prostate cancer. Previous work has shown that androgens can drive the expression of alternative mRNA isoforms as well as transcriptional changes in prostate cancer ... -
Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells.
(BioMed Central, 2015-01-16)BACKGROUND: Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients ... -
Anesthesia and Monitoring of Animals During MRI Studies.
(2018)The use of imaging represents a major impact on the refinement and the reduction of in vivo studies in animal models, in particular for allowing longitudinal monitoring of the onset and the progression of disease within ... -
Antagonism between FOXO and MYC Regulates Cellular Powerhouse.
(Frontiers Media SA, 2013-04-25)Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis ... -
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer
(Impact Journals, 2018-10-09)Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to suppress cell growth of breast cancer cells in vitro. In this study we further explore the inhibitory effects of this molecule in ... -
Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn's disease.
(2023-12-06)In vivo apoptosis of human mesenchymal stromal cells (MSCs) plays a critical role in delivering immunomodulation. Yet, caspase activity not only mediates the dying process but also death-independent functions that may shape ... -
Approaching Cancer Evolution from Different Angles
(Cell Press, 2020-10-22)Dr Francesca Ciccarelli (The Francis Crick Institute, UK) and Dr James De Gregori (University of Colorado, USA) interview 3 top scientists in clinical (Dr Charles Swanton, The Francis Crick Institute, UK), molecular (Dr ...