Browsing Barts Cancer Institute by Title
Now showing items 1055-1074 of 1165
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Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.
(2010-05-27)Surface IgM (sIgM) has a key influence on the clinical behavior of chronic lymphocytic leukemia (CLL). We now report that it exists in 2 forms with different N-glycosylation patterns in the mu-constant region. One glycoform ... -
Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.
(2012-01-05)Although long considered as a disease of failed apoptosis, it is now clear that chronic lymphocytic leukemia (CLL) cells undergo extensive cell division in vivo, especially in progressive disease. Signaling via the B-cell ... -
Surgical decision making in premenopausal BRCA carriers considering risk reducing early-salpingectomy or salpingo-oophorectomy: a Qualitative Study
Background: Acceptance of the role of the fallopian tube in “ovarian” carcinogenesis and the detrimental sequelae of surgical menopause in pre-menopausal women following risk-reducing-salpingo-oophorectomy (RRSO), has ... -
Surgical pelvic anatomy in gynecologic oncology.
(2018-10)Laparoscopy, with its many advantages, has revolutionized the field of pelvic surgery and enabled surgeons to gain a far greater understanding of pelvic anatomy. As technology evolves, our understanding is continuously ... -
Switchable CAR-T cells mediate long-term remission of PDAC
(Elsevier, 2020-12) -
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma.
(2018-08-18)OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy ... -
Syrian Hamster as an Animal Model for the Study on Infectious Diseases
(Frontiers Media, 2019-10-01)Infectious diseases still remain one of the biggest challenges for human health. In order to gain a better understanding of the pathogenesis of infectious diseases and develop effective diagnostic tools, therapeutic ... -
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
(American Society of Hematology, 2020-11-05) -
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer.
(2019-09-06)Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered intratumorally, resulting in local tumour elimination. Entrapment and binding ...