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dc.contributor.authorWald, NJen_US
dc.contributor.authorMorris, JKen_US
dc.contributor.authorBlakemore, Cen_US
dc.date.accessioned2018-03-13T11:36:33Z
dc.date.available2018-01-08en_US
dc.date.issued2018en_US
dc.date.submitted2018-03-11T07:41:00.201Z
dc.identifier.issn0301-0422en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/34984
dc.description.abstractThe neural tube defects anencephaly and spina bifida are two of the most common serious congenital malformations. Most cases can be prevented by consuming sufficient folic acid immediately before pregnancy and in early pregnancy. Fortification of flour with folic acid to prevent these defects has been implemented in 81 countries without public objection or indication of harm. An obstacle to the wider adoption of fortification arises from the creation of a "tolerable upper intake level" for folate (which includes natural food folate as well as synthetic folic acid), and which has been set at 1 mg/day, thereby proscribing higher folate intakes. Increasing the intake of folic acid in a population will necessarily increase the number of people with a folate intake greater than 1 mg per day, and this concern is obstructing folic acid fortification. This paper shows that the scientific basis for setting any upper limit, let alone one at 1 mg/day, is flawed. An upper intake level is therefore unnecessary and should be removed, thus allaying unjustified concerns about folic acid fortification. As a result, the full global opportunity to prevent two serious fatal or disabling disorders can and should be realized.en_US
dc.format.extent2 - ?en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofPublic Health Reven_US
dc.subjectAnencephalyen_US
dc.subjectFolateen_US
dc.subjectFolic aciden_US
dc.subjectNeural tube defectsen_US
dc.subjectSpina bifidaen_US
dc.subjectTolerable upper intake levelen_US
dc.titlePublic health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate.en_US
dc.typeArticle
dc.identifier.doi10.1186/s40985-018-0079-6en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29450103en_US
pubs.notesNot knownen_US
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Wolfson Institute of Preventive Medicine
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Wolfson Institute of Preventive Medicine/Environmental & Preventive Medicine
pubs.organisational-group/Queen Mary University of London/REF
pubs.organisational-group/Queen Mary University of London/REF/REF - SMD - Wolfson
pubs.organisational-group/Queen Mary University of London/REF/REF - UoA 01
pubs.publication-statusPublished onlineen_US
pubs.volume39en_US
dcterms.dateAccepted2018-01-08en_US


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