Adaptive from Innate: Human IFN-γ+CD4+T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.
1696 - 1705
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We recently demonstrated that the major effector function of neonatal CD4+T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ-producing CD4+T cells. Thus, the temporal transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellular level by the capacity of human innate-like CXCL8-producing CD4+T cells to transition directly into Th1 cells.
AuthorsDas, A; Rouault-Pierre, K; Kamdar, S; Gomez-Tourino, I; Wood, K; Donaldson, I; Mein, CA; Bonnet, D; Hayday, AC; Gibbons, DL
- Genomic Medicine