Browsing School of Engineering and Materials Science by Subject "Xenograft"

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    • Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold based xenograft model 

      Sontakke, P; Carretta, M; Jaques, J; Brouwers-Vos, AZ; Lubbers-Aalders, L; Yuan, H; de Bruijn, JD; Martens, AC; Vellenga, E; Groen, RW (Nature Publishing Group, 2016-05-17)
      While NOD-SCID IL2Rγ(-/-) (NSG) xenograft mice are currently the most frequently used model to study human leukemia in vivo, the absence of a human niche severely hampers faithful recapitulation of the disease. We used NSG ...