Browsing School of Engineering and Materials Science by Author "Vellenga, E"
Now showing items 1-6 of 6
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Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches
Antonelli, A; Noort, WA; Jaques, J; de Boer, B; de Jong-Korlaar, R; Brouwers-Vos, AZ; Lubbers-Aalders, L; van Velzen, JF; Bloem, AC; Yuan, H (American Society of Hematology, 2016-12-22)To begin to understand the mechanisms that regulate self-renewal, differentiation, and transformation of human hematopoietic stem cells or to evaluate the efficacy of novel treatment modalities, stem cells need to be ... -
Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches
Antonelli, A; Noort, WA; Jaques, J; de Boer, B; de Jong-Korlaar, R; Brouwers-Vos, AZ; Lubbers-Aalders, L; van Velzen, JF; Bloem, AC; Yuan, H (2016-12-22) -
Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches.
Antonelli, A; Noort, WA; Jaques, J; de Boer, B; de Jong-Korlaar, R; Brouwers-Vos, AZ; Lubbers-Aalders, L; van Velzen, JF; Bloem, AC; Yuan, H (2016-10-12)To begin to understand the mechanisms that regulate self-renewal, differentiation, and transformation of human hematopoietic stem cells or to evaluate the efficacy of novel treatment modalities, stem cells need to be studied ... -
Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models
Carretta, M; de Boer, B; Jaques, J; Antonelli, A; Horton, SJ; Yuan, H; de Bruijn, JD; Groen, RWJ; Vellenga, E; Schuringa, JJ (2017-07) -
Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold based xenograft model
Sontakke, P; Carretta, M; Jaques, J; Brouwers-Vos, AZ; Lubbers-Aalders, L; Yuan, H; de Bruijn, JD; Martens, AC; Vellenga, E; Groen, RW (Nature Publishing Group, 2016-05-17)While NOD-SCID IL2Rγ(-/-) (NSG) xenograft mice are currently the most frequently used model to study human leukemia in vivo, the absence of a human niche severely hampers faithful recapitulation of the disease. We used NSG ... -
Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model
Sontakke, P; Carretta, M; Jaques, J; Brouwers-Vos, AZ; Lubbers-Aalders, L; Yuan, H; de Bruijn, JD; Martens, ACM; Vellenga, E; Groen, RWJ (2016-10)